(To the tune of "Close to You")
Copyright 2009 Kevin Ahern

This is a song that I am very proud of because everything came together in it perfectly. Barbara Gladstone's singing and Neal Gladstone's accompaniment capture the spirit of Karen Carpenter's original recording of "Close to You" superbly. I wrote the lyrics on a wonderful weekend trip to the Oregon coast with Indira. When I have quiet time, I like to write lyrics and this was a perfect setup. I'm also pleased with this song because it covers the topic of enzymes well without overloapping with another song I wrote called "Enzymes." Clearly, this is one of my favorites. You can download the MP3 recording HERE and you should also check out Neal Gladstone's Music HERE.

My enzymes
Truly are inclined
To convert
Things they bind
Turn the key

How do cells
Regulate these roles?
-ic controls
Two forms, see
States R and T

Competing inhibition keeps 
The substrates from the active site
They raise Km, but leave Vmax and shirk
While the non-competers bind elsewhere
And lift the plot made on Lineweaver-Burk

Other ways
Enzymes can be blocked
When things bind
Then get locked
Stuck not free
Tied to the key

Penicillin’s action stops
Peptidoglycan cross-links in
Bacterial cell walls in awesome ways
Beta lactam ring’s reactive site
Starts bonding with D-D-transpeptidase

So there are
Several enzyme states
-ing substrates
Now you see
Blocking the key

Have to be controlled
Some get slowed
Put on hold
It's sublime
How the enzymes
(slow) Cat-a-lyze

ahhhhhhhhhhhhhhhhhhh - cat-a-lyze
ahhhhhhhhhhhhhhhhhhh - cat-a-lyze
ahhhhhhhhhhhhhhhhhhh - cat-a-lyze

Web Page of the Metabolic Melodies HERE


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