Kevin Ahern's Wildly Popular Metabolic Melodies, Limericks, and Verses

I Wanna Hold Your Strands

(to the tune of "I Wanna Hold Your Hand")

Oh yeah, I’ll tell you something

It helps to understand

Pol III de-crees

To meet the cell’s demands

It has to hold the straaaaaands

It’s gotta hold the strands

The key, Pol III

Acts most processively

‘Cuz see, Pol III

Has beta clamping ha-a-a-a-ands

It uses beta’s ba-a-a-a-a-a-ands (note this is ‘bands,’ not ‘hands’)

To hold onto the strands

As it starts rep-li-CAT-ING a d---N-A (emphasis as noted)

The un-win-DING requires a lone

Helicase

Helica-a-a-a-a-a-a-ase!

Pri-mase starts the primer

That Pol I can erase

Pol III takes the primer

And starts the DNAs

It starts the DNA-a-a-a-as

By using RNA

And when a fragment Okazaki - displays

There must be joining

That requires

A ligase

A liga-a-a-a-ase

Thanks to all the factors

And all of their ligands

The cell has what matters

To replicate the strands

It replicates the strands

It replicates the stra-a-a-a-a-a-a-a-ands

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