Serine Protease Song
(To the tune of "Blackbird")
Copyright © 2011 Kevin Ahern

David Simmons' recording HERE

Substrate floating in the cell’s insides

Enzyme snags it with its binding site

It supplies

Shuffling of electrons in the act to catalyze

 

Proteases of the serine kind

Break up peptide bonds in rapid time

Fast and slow

Steps in breaking bonds are mechanisms you should know

 

Asp – his - ser

Bonds beware

Inside the S1 pocket substrate sits

 

Alkoxides

Break peptides

Nucleophiles give bonds the fits

 

Peptide one exits easily

But water has to let the other flee

Bound not free

 ‘Cuz the enzyme’s linked to it in mechanism three

 

When it’s gone the enzyme’s free to catalyze you see

When it’s gone the enzyme’s free to catalyze you see

 

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